[HTML][HTML] RB· E2F1 complex mediates DNA damage responses through transcriptional regulation of ZBRK1
CC Liao, CY Tsai, WC Chang, WH Lee… - Journal of biological …, 2010 - ASBMB
RB plays an essential role in DNA damage-induced growth arrest and regulates the
expression of several factors essential for DNA repair machinery. However, how RB
coordinates DNA damage response through transcriptional regulation of genes involved in
growth arrest remains largely unexplored. We examined whether RB can mediate the
response to DNA damage through modulation of ZBRK1, a zinc finger-containing
transcriptional repressor that can modulate the expression of GADD45A, a DNA damage …
expression of several factors essential for DNA repair machinery. However, how RB
coordinates DNA damage response through transcriptional regulation of genes involved in
growth arrest remains largely unexplored. We examined whether RB can mediate the
response to DNA damage through modulation of ZBRK1, a zinc finger-containing
transcriptional repressor that can modulate the expression of GADD45A, a DNA damage …