[HTML][HTML] Modification of the DNA damage response by therapeutic CDK4/6 inhibition
JL Dean, AK McClendon, ES Knudsen - Journal of Biological Chemistry, 2012 - ASBMB
The RB/E2F axis represents a critical node of cell signaling that integrates a diverse array of
signaling pathways. Recent evidence has suggested a role for E2F-mediated gene
transcription in DNA damage response and repair, as well as apoptosis signaling. Herein,
we investigated how repression of E2F activity via CDK4/6 inhibition and RB activation
impacts the response of triple negative breast cancer (TNBC) to frequently used therapeutic
agents. In combination with taxanes and anthracyclines CDK4/6 inhibition and consequent …
signaling pathways. Recent evidence has suggested a role for E2F-mediated gene
transcription in DNA damage response and repair, as well as apoptosis signaling. Herein,
we investigated how repression of E2F activity via CDK4/6 inhibition and RB activation
impacts the response of triple negative breast cancer (TNBC) to frequently used therapeutic
agents. In combination with taxanes and anthracyclines CDK4/6 inhibition and consequent …