Regulation of chemokine-induced lymphocyte migration by RGS proteins
C Moratz, K Harrison, JH Kehrl - Methods in enzymology, 2004 - Elsevier
G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by inducing the G-
protein α (Gα) subunit to exchange guanosine diphosphate for guanosine triphosphate.
Regulators of G-protein signaling (RGS) proteins enhance the deactivation of Gα subunits,
thereby reducing the activation of downstream effectors. Several members of the RGS family
are expressed in lymphocytes. Among RGS proteins with the highest levels of expression
are RGS1, RGS2, RGS10, RGS13, RGS14, RGS16, and RGS19. Perhaps the most …
protein α (Gα) subunit to exchange guanosine diphosphate for guanosine triphosphate.
Regulators of G-protein signaling (RGS) proteins enhance the deactivation of Gα subunits,
thereby reducing the activation of downstream effectors. Several members of the RGS family
are expressed in lymphocytes. Among RGS proteins with the highest levels of expression
are RGS1, RGS2, RGS10, RGS13, RGS14, RGS16, and RGS19. Perhaps the most …
