Women of reproductive age are protected from metabolic disease relative to
postmenopausal women and men. Most preclinical rodent studies are skewed toward the
use of male mice to study obesity-induced metabolic dysfunction because of a similar
protection observed in female mice. How sex differences in obesity-induced inflammatory
responses contribute to these observations is unknown. We have compared and contrasted
the effects of high fat diet-induced obesity on glucose metabolism and leukocyte activation in …