RNA editing by adenosine deaminases that act on RNA
BL Bass - Annual review of biochemistry, 2002 - annualreviews.org
▪ Abstract ADARs are RNA editing enzymes that target double-stranded regions of nuclear-
encoded RNA and viral RNA. These enzymes are particularly abundant in the nervous
system, where they diversify the information encoded in the genome, for example, by
altering codons in mRNAs. The functions of ADARs in known substrates suggest that the
enzymes serve to fine-tune and optimize many biological pathways, in ways that we are only
starting to imagine. ADARs are also interesting in regard to the remarkable double-stranded …
encoded RNA and viral RNA. These enzymes are particularly abundant in the nervous
system, where they diversify the information encoded in the genome, for example, by
altering codons in mRNAs. The functions of ADARs in known substrates suggest that the
enzymes serve to fine-tune and optimize many biological pathways, in ways that we are only
starting to imagine. ADARs are also interesting in regard to the remarkable double-stranded …
