Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1
JC Hartner, C Schmittwolf, A Kispert, AM Muller… - Journal of Biological …, 2004 - jbc.org
ADAR1 (adenosine deaminase acting on RNA-1) is widely expressed in mammals, but its
biological role is unknown. We show here by gene targeting that ADAR1 selectively edits in
vivo two of five closely spaced adenosines in the serotonin 5-hydroxytryptamine subtype 2C
receptor pre-mRNA of nervous tissue; and hence, site-selective adenosine-to-inosine
editing is indeed a function of ADAR1. Remarkably, homozygosity for two different null
alleles of ADAR1 caused a consistent embryonic phenotype appearing early at embryonic …
biological role is unknown. We show here by gene targeting that ADAR1 selectively edits in
vivo two of five closely spaced adenosines in the serotonin 5-hydroxytryptamine subtype 2C
receptor pre-mRNA of nervous tissue; and hence, site-selective adenosine-to-inosine
editing is indeed a function of ADAR1. Remarkably, homozygosity for two different null
alleles of ADAR1 caused a consistent embryonic phenotype appearing early at embryonic …