Double-stranded RNA sensors and modulators in innate immunity
S Hur - Annual review of immunology, 2019 - annualreviews.org
Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune
defense in many organisms. We here discuss several families of dsRNA-binding proteins
involved in mammalian antiviral innate immunity. These include RIG-I-like receptors, protein
kinase R, oligoadenylate synthases, adenosine deaminases acting on RNA, RNA
interference systems, and other proteins containing dsRNA-binding domains and helicase
domains. Studies suggest that their functions are highly interdependent and that their …
defense in many organisms. We here discuss several families of dsRNA-binding proteins
involved in mammalian antiviral innate immunity. These include RIG-I-like receptors, protein
kinase R, oligoadenylate synthases, adenosine deaminases acting on RNA, RNA
interference systems, and other proteins containing dsRNA-binding domains and helicase
domains. Studies suggest that their functions are highly interdependent and that their …