[HTML][HTML] Regulation of Na+ reabsorption by the aldosterone-induced small G protein K-Ras2A
JD Stockand, BJ Spier, RT Worrell, G Yue… - Journal of Biological …, 1999 - ASBMB
Xenopus laevis A6 cells were used as model epithelia to test the hypothesis that K-Ras2A is
an aldosterone-induced protein necessary for steroid-regulated Na+ transport. The
possibility that increased K-Ras2A alone is sufficient to mimic aldosterone action on Na+
transport also was tested. Aldosterone treatment increased K-Ras2A protein expression 2.8-
fold within 4 h. Active Ras is membrane associated. After aldosterone treatment, 75% of K-
Ras was localized to the plasma membrane compared with 25% in the absence of steroid …
an aldosterone-induced protein necessary for steroid-regulated Na+ transport. The
possibility that increased K-Ras2A alone is sufficient to mimic aldosterone action on Na+
transport also was tested. Aldosterone treatment increased K-Ras2A protein expression 2.8-
fold within 4 h. Active Ras is membrane associated. After aldosterone treatment, 75% of K-
Ras was localized to the plasma membrane compared with 25% in the absence of steroid …