Hypothalamic sensing of fatty acids

TKT Lam, GJ Schwartz, L Rossetti - Nature neuroscience, 2005 - nature.com
TKT Lam, GJ Schwartz, L Rossetti
Nature neuroscience, 2005nature.com
Selective regions of the brain, including the hypothalamus, are capable of gathering
information on the body's nutritional status in order to implement appropriate behavioral and
metabolic responses to changes in fuel availability. This review focuses on direct metabolic
signaling within the hypothalamus. There is growing evidence supporting the idea that fatty
acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient
availability that can integrate multiple nutritional and hormonal signals.
Abstract
Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responses to changes in fuel availability. This review focuses on direct metabolic signaling within the hypothalamus. There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals.
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