[HTML][HTML] The metalloprotease disintegrin ADAM8: processing by autocatalysis is required for proteolytic activity and cell adhesion
U Schlomann, D Wildeboer, A Webster… - Journal of biological …, 2002 - ASBMB
ADAMs (adisintegrinand metalloprotease domains) are metalloprotease and disintegrin
domain-containing transmembrane glycoproteins with proteolytic, cell adhesion, cell fusion,
and cell signaling properties. ADAM8 was originally cloned from monocytic cells, and its
distinct expression pattern indicates possible roles in both immunology and neuropathology.
Here we describe our analysis of its biochemical properties. In transfected COS-7 cells,
ADAM8 is localized to the plasma membrane and processed into two forms derived either by …
domain-containing transmembrane glycoproteins with proteolytic, cell adhesion, cell fusion,
and cell signaling properties. ADAM8 was originally cloned from monocytic cells, and its
distinct expression pattern indicates possible roles in both immunology and neuropathology.
Here we describe our analysis of its biochemical properties. In transfected COS-7 cells,
ADAM8 is localized to the plasma membrane and processed into two forms derived either by …