A disintegrin and metalloprotease (ADAM) family members, characterized by a
metalloprotease and a disintegrin domain, are membrane-anchored glycoproteins involved
in proteolysis and cell adhesion. ADAM8 is specifically induced in the experimental murine
asthmatic lung. To evaluate novel pathways involved in asthma pathogenesis, using ADAM8
transgenic mice (ATMS2) in a murine model of asthma. Massive cellular infiltrates in
peribronchovascular and interstitial lesions were observed in control mice, while in ATMS2 …