Mammalian ceramide synthases
M Levy, AH Futerman - IUBMB life, 2010 - Wiley Online Library
M Levy, AH Futerman
IUBMB life, 2010•Wiley Online LibraryIn mammals, ceramide, a key intermediate in sphingolipid metabolism and an important
signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of
which synthesizes ceramides with distinct acyl chain lengths. There are a number of
common biochemical features between the CerS, such as their catalytic mechanism, and
their structure and intracellular localization. Different CerS also display remarkable
differences in their biological properties, with each of them playing distinct roles in …
signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of
which synthesizes ceramides with distinct acyl chain lengths. There are a number of
common biochemical features between the CerS, such as their catalytic mechanism, and
their structure and intracellular localization. Different CerS also display remarkable
differences in their biological properties, with each of them playing distinct roles in …
Abstract
In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common biochemical features between the CerS, such as their catalytic mechanism, and their structure and intracellular localization. Different CerS also display remarkable differences in their biological properties, with each of them playing distinct roles in processes as diverse as cancer and tumor suppression, in the response to chemotherapeutic drugs, in apoptosis, and in neurodegenerative diseases. © 2010 IUBMB IUBMB Life, 62(5): 347–356, 2010
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