Smoking is associated with mosaic loss of chromosome Y
JP Dumanski, C Rasi, M Lönn, H Davies, M Ingelsson… - Science, 2015 - science.org
JP Dumanski, C Rasi, M Lönn, H Davies, M Ingelsson, V Giedraitis, L Lannfelt…
Science, 2015•science.orgTobacco smoking is a risk factor for numerous disorders, including cancers affecting organs
outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk
factor for these cancers in males compared with females. This observation, together with the
fact that males have a higher incidence of and mortality from most non–sex-specific cancers,
remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with
increased risk of nonhematological tumors. We demonstrate here that smoking is associated …
outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk
factor for these cancers in males compared with females. This observation, together with the
fact that males have a higher incidence of and mortality from most non–sex-specific cancers,
remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with
increased risk of nonhematological tumors. We demonstrate here that smoking is associated …
Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non–sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.
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