X and Y chromosome loss as sole abnormality in acute non-lymphocytic leukemia (ANLL)
CB Riske, R Morgan, S Ondreyco… - Cancer genetics and …, 1994 - Elsevier
Of the 9300 bone marrows and peripheral bloods analyzed for hematologic disease in our
laboratory between 1978 and 1990, 240 patients exhibited X or Y loss of chromosomes. Of
those 240 patients only two could be positively associated with acute leukemia and no other
observable chromosome involvement. The evidence presented here, albeit represented by
only two patients, proves that sex chromosome loss as the sole abnormality can be a clonal
cytogenetic marker for acute leukemia. One patient was a 48-year-old man with loss of the Y …
laboratory between 1978 and 1990, 240 patients exhibited X or Y loss of chromosomes. Of
those 240 patients only two could be positively associated with acute leukemia and no other
observable chromosome involvement. The evidence presented here, albeit represented by
only two patients, proves that sex chromosome loss as the sole abnormality can be a clonal
cytogenetic marker for acute leukemia. One patient was a 48-year-old man with loss of the Y …