[HTML][HTML] Pro-inflammatory macrophages sustain pyruvate oxidation through pyruvate dehydrogenase for the synthesis of itaconate and to enable cytokine expression
J Meiser, L Krämer, SC Sapcariu, N Battello… - Journal of Biological …, 2016 - ASBMB
Upon stimulation with Th1 cytokines or bacterial lipopolysaccharides, resting macrophages
shift their phenotype toward a pro-inflammatory state as part of the innate immune response.
LPS-activated macrophages undergo profound metabolic changes to adapt to these new
physiological requirements. One key step to mediate this metabolic adaptation is the
stabilization of HIF1α, which leads to increased glycolysis and lactate release, as well as
decreased oxygen consumption. HIF1 abundance can result in the induction of the gene …
shift their phenotype toward a pro-inflammatory state as part of the innate immune response.
LPS-activated macrophages undergo profound metabolic changes to adapt to these new
physiological requirements. One key step to mediate this metabolic adaptation is the
stabilization of HIF1α, which leads to increased glycolysis and lactate release, as well as
decreased oxygen consumption. HIF1 abundance can result in the induction of the gene …