Lethal malaria: Marchiafava and Bignami were right
The Journal of infectious diseases, 2013•academic.oup.com
One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami
proposed that the fundamental pathological process underlying lethal falciparum malaria
was microvascular obstruction. Since then, several alternative hypotheses have been
proposed. These formed the basis for adjunctive interventions, which have either been
ineffective or harmful. Recent evidence strongly suggests that Marchiafava and Bignami
were right.
proposed that the fundamental pathological process underlying lethal falciparum malaria
was microvascular obstruction. Since then, several alternative hypotheses have been
proposed. These formed the basis for adjunctive interventions, which have either been
ineffective or harmful. Recent evidence strongly suggests that Marchiafava and Bignami
were right.
Abstract
One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami proposed that the fundamental pathological process underlying lethal falciparum malaria was microvascular obstruction. Since then, several alternative hypotheses have been proposed. These formed the basis for adjunctive interventions, which have either been ineffective or harmful. Recent evidence strongly suggests that Marchiafava and Bignami were right.
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