Classification of adhesive domains in the Plasmodium falciparum erythrocyte membrane protein 1 family
The Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) family of
cytoadherent proteins has a central role in disease from malaria infection. This highly
diverse gene family is involved in binding interactions between infected erythrocytes and
host cells and is expressed in a clonally variant pattern at the erythrocyte surface. We
describe by sequence analysis the structure and domain organization of 20 PfEMP1 from
the GenBank database. Four domains comprise the majority of PfEMP1 extracellular …
cytoadherent proteins has a central role in disease from malaria infection. This highly
diverse gene family is involved in binding interactions between infected erythrocytes and
host cells and is expressed in a clonally variant pattern at the erythrocyte surface. We
describe by sequence analysis the structure and domain organization of 20 PfEMP1 from
the GenBank database. Four domains comprise the majority of PfEMP1 extracellular …
