[HTML][HTML] Plasmodium falciparum‐infected erythrocytes induce tissue factor expression in endothelial cells and support the assembly of multimolecular coagulation …
Background: Plasmodium falciparum malaria infects 300–500 million people every year,
causing 1–2 million deaths annually. Evidence of a coagulation disorder, activation of
endothelial cells (EC) and increase in inflammatory cytokines are often present in malaria.
Objectives: We have asked whether interaction of parasitized red blood cells (pRBC) with
EC induces tissue factor (TF) expression in vitro and in vivo. The role of phosphatidylserine‐
containing pRBC to support the assembly of blood coagulation complexes was also …
causing 1–2 million deaths annually. Evidence of a coagulation disorder, activation of
endothelial cells (EC) and increase in inflammatory cytokines are often present in malaria.
Objectives: We have asked whether interaction of parasitized red blood cells (pRBC) with
EC induces tissue factor (TF) expression in vitro and in vivo. The role of phosphatidylserine‐
containing pRBC to support the assembly of blood coagulation complexes was also …