Inhibition of experimental acute pulmonary inflammation by pirfenidone
J Spond, N Case, RW Chapman, Y Crawley… - Pulmonary …, 2003 - Elsevier
Pirfenidone, a putative tumor necrosis factor-α (TNF-α) inhibitor, has recently gained
recognition for its therapeutic use in the treatment of idiopathic pulmonary fibrosis. As
pulmonary fibrosis may be the result of lung inflammatory processes, we examined the anti-
inflammatory potential of pirfenidone in several models of acute pulmonary inflammation. In
antigen-induced allergic paradigms, 24 h after antigen challenge, sensitized mice or guinea
pigs develop a prominent pulmonary inflammation, reflected by a significant increase in the …
recognition for its therapeutic use in the treatment of idiopathic pulmonary fibrosis. As
pulmonary fibrosis may be the result of lung inflammatory processes, we examined the anti-
inflammatory potential of pirfenidone in several models of acute pulmonary inflammation. In
antigen-induced allergic paradigms, 24 h after antigen challenge, sensitized mice or guinea
pigs develop a prominent pulmonary inflammation, reflected by a significant increase in the …
