Pirfenidone inhibits the induction of iNOS stimulated by interleukin-1β at a step of NF-κB DNA binding in hepatocytes
H Nakanishi, M Kaibori, S Teshima, H Yoshida… - Journal of …, 2004 - Elsevier
BACKGROUND/AIMS: Pirfenidone has antiinflammatory effects in animals with
endotoxemia. We reported that pirfenidone inhibits the enhancement of inflammatory
cytokines and inducible nitric oxide synthase (iNOS) in liver of endotoxin-treated rats,
leading to the prevention of hepatic injury. However, the mechanisms involved in
suppression of these gene inductions are obscure. Studies were performed to investigate
whether pirfenidone directly influences iNOS induction in hepatocytes. METHODS: Cultured …
endotoxemia. We reported that pirfenidone inhibits the enhancement of inflammatory
cytokines and inducible nitric oxide synthase (iNOS) in liver of endotoxin-treated rats,
leading to the prevention of hepatic injury. However, the mechanisms involved in
suppression of these gene inductions are obscure. Studies were performed to investigate
whether pirfenidone directly influences iNOS induction in hepatocytes. METHODS: Cultured …