High serum levels of high-mobility group box 1 (HMGB1) and low levels of heat shock protein 70 (Hsp70) are associated with poor prognosis in patients with acute …
L Arriaga-Pizano, I Boscó-Gárate… - Archives of Medical …, 2018 - Elsevier
Introduction Cell damage in Acute Pancreatitis (AP) lead to release of cytokines and HMGB1
and Hsp70. While Hsp70 plays a role in cytoprotection, when released to extracellular milieu
constitutes, as HMGB1, a danger signal and trigger pro-inflammatory responses. These
molecules seem to be related to the clinical progression; but because no evidence exists
about them as molecular network in AP development, we quantify HSP70, HMGB1, and
cytokines in patients with AP and search for correlations with severity and prognosis …
and Hsp70. While Hsp70 plays a role in cytoprotection, when released to extracellular milieu
constitutes, as HMGB1, a danger signal and trigger pro-inflammatory responses. These
molecules seem to be related to the clinical progression; but because no evidence exists
about them as molecular network in AP development, we quantify HSP70, HMGB1, and
cytokines in patients with AP and search for correlations with severity and prognosis …