Relationship of neuroendocrine cells of prostate and serotonin to benign prostatic hyperplasia

ATK Cockett, PA di Sant'Agnese, P Gopinath… - Urology, 1993 - Elsevier
Neuroendocrine (NE) cells containing neurosecretory granules, rich in various peptide
hormones and biogenic amines such as serotonin (5-HT), are components of the human
prostate epithelium. The NE cells probably subserve a paracrine or local regulatory role in
both prostatic growth and differentiation as well as the exocrine secretory process.
Neuroendocrine cells may be involved in the etiology of benign prostatic hyperplasia (BPH).
In this study the number of NE cells in areas of BPH was compared with normal tissue using …