BMP receptor signaling: transcriptional targets, regulation of signals, and signaling cross-talk
K Miyazono, S Maeda, T Imamura - Cytokine & growth factor reviews, 2005 - Elsevier
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β)
superfamily, bind to two different serine/threonine kinase receptors, and mediate their
signals through Smad-dependent and Smad-independent pathways. Receptor regulated-
Smad (R-Smad) proteins specific for the BMP pathways interact with various proteins,
including transcription factor Runx, and transmit specific signals in target cells. The recent
development of DNA microarray techniques has allowed us to identify many BMP target …
superfamily, bind to two different serine/threonine kinase receptors, and mediate their
signals through Smad-dependent and Smad-independent pathways. Receptor regulated-
Smad (R-Smad) proteins specific for the BMP pathways interact with various proteins,
including transcription factor Runx, and transmit specific signals in target cells. The recent
development of DNA microarray techniques has allowed us to identify many BMP target …