[HTML][HTML] Activation of Notch-1 in oral epithelial cells by P. gingivalis triggers the expression of the antimicrobial protein PLA2-IIA
A Al-Attar, Y Alimova, S Kirakodu, A Kozal, MJ Novak… - Mucosal …, 2018 - Elsevier
P. gingivalis (Pg) is an oral pathogen with the ability to induce oral dysbiosis and periodontal
disease. Nevertheless, the mechanisms by which mucosal responses to the oral microbiota
in the presence of specific pathogens such as Pg could abrogate the host-microbe symbiotic
relationship leading to periodontitis remain unclear. Herein, we identified the Notch-1/PLA 2-
IIA axis as a new molecular pathway through which Pg could be specifically modulating oral
epithelial antimicrobial and inflammatory responses. Pg activated Notch-1, and inhibition or …
disease. Nevertheless, the mechanisms by which mucosal responses to the oral microbiota
in the presence of specific pathogens such as Pg could abrogate the host-microbe symbiotic
relationship leading to periodontitis remain unclear. Herein, we identified the Notch-1/PLA 2-
IIA axis as a new molecular pathway through which Pg could be specifically modulating oral
epithelial antimicrobial and inflammatory responses. Pg activated Notch-1, and inhibition or …