Extracellular phospholipase A2 secretion is a common effector pathway of interleukin-1 and tumour necrosis factor action
P Vadas, W Pruzanski, E Stefanski, LG Ellies… - Immunology letters, 1991 - Elsevier
Inflammatory processes are characterised by increased levels of extracellular
phospholipase A2 (PLA2) and cytokines such as interleukin 1 (IL-1) and tumour necrosis
factor (TNF). IL-1, TNF and PLA2 share a number of proinflammatory, arthritogenic effects.
The sequential induction, first of the cytokines followed by PLA2, suggests that these
cytokines may regulate synthesis and secretion of PLA2. To test this postulate, foetal rat
calvarial bone-forming cells (FRCC) were treated with recombinant human IL-1 and TNF …
phospholipase A2 (PLA2) and cytokines such as interleukin 1 (IL-1) and tumour necrosis
factor (TNF). IL-1, TNF and PLA2 share a number of proinflammatory, arthritogenic effects.
The sequential induction, first of the cytokines followed by PLA2, suggests that these
cytokines may regulate synthesis and secretion of PLA2. To test this postulate, foetal rat
calvarial bone-forming cells (FRCC) were treated with recombinant human IL-1 and TNF …