[HTML][HTML] On the binding preference of human groups IIA and X phospholipases A2 for membranes with anionic phospholipids
S Bezzine, JG Bollinger, AG Singer, SL Veatch… - Journal of Biological …, 2002 - ASBMB
Mammals contain 9–10 secreted phospholipases A 2 (sPLA 2 s) that display widely different
affinities for membranes, depending on the phospholipid composition. The much higher
enzymatic activity of human group X sPLA 2 (hGX) compared with human group IIA sPLA 2
(hGIIA) on phosphatidylcholine (PC)-rich vesicles is due in large part to the higher affinity of
the former enzyme for such vesicles; this result also holds when vesicles contain cholesterol
and sphingomyelin. The inclusion of anionic phosphatidylserine in PC vesicles dramatically …
affinities for membranes, depending on the phospholipid composition. The much higher
enzymatic activity of human group X sPLA 2 (hGX) compared with human group IIA sPLA 2
(hGIIA) on phosphatidylcholine (PC)-rich vesicles is due in large part to the higher affinity of
the former enzyme for such vesicles; this result also holds when vesicles contain cholesterol
and sphingomyelin. The inclusion of anionic phosphatidylserine in PC vesicles dramatically …