Secretory phospholipase A2 of group IIA: is it an offensive or a defensive player during atherosclerosis and other inflammatory diseases?
M Menschikowski, A Hagelgans, G Siegert - Prostaglandins & other lipid …, 2006 - Elsevier
Since its discovery in the serum of patients with severe inflammation and in rheumatoid
arthritic fluids, the secretory phospholipase A2 of group IIA (sPLA2-IIA) has been chiefly
considered as a proinflammatory enzyme, the result of which has been very intense interest
in selective inhibitors of sPLA2-IIA in the hope of developing new and efficient therapies for
inflammatory diseases. The recent discovery of the antibacterial properties of sPLA2-IIA,
however, has raised the question of whether the upregulation of sPLA2-IIA during …
arthritic fluids, the secretory phospholipase A2 of group IIA (sPLA2-IIA) has been chiefly
considered as a proinflammatory enzyme, the result of which has been very intense interest
in selective inhibitors of sPLA2-IIA in the hope of developing new and efficient therapies for
inflammatory diseases. The recent discovery of the antibacterial properties of sPLA2-IIA,
however, has raised the question of whether the upregulation of sPLA2-IIA during …