Depletion of bone marrow–derived macrophages perturbs the innate immune response to surgery and reduces postoperative memory dysfunction

V Degos, S Vacas, Z Han, N van Rooijen… - The Journal of the …, 2013 - pubs.asahq.org
Background: According to rodent models of postoperative cognitive decline, activation of the
innate immune response following aseptic surgical trauma results in the elaboration of
hippocampal proinflammatory cytokines, which are capable of disrupting long-term
potentiation, the neurobiologic correlate of memory. The authors hypothesize that
hippocampal recruitment of bone marrow–derived macrophages plays a causal role in these
processes, resulting in memory dysfunction. Methods: Clodrolip injection (liposomal …