[HTML][HTML] Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase
YT Wu, HL Tan, G Shui, C Bauvy, Q Huang… - Journal of Biological …, 2010 - ASBMB
A group of phosphoinositide 3-kinase (PI3K) inhibitors, such as 3-methyladenine (3-MA) and
wortmannin, have been widely used as autophagy inhibitors based on their inhibitory effect
on class III PI3K activity, which is known to be essential for induction of autophagy. In this
study, we systematically examined and compared the effects of these two inhibitors on
autophagy under both nutrient-rich and deprivation conditions. To our surprise, 3-MA is
found to promote autophagy flux when treated under nutrient-rich conditions with a …
wortmannin, have been widely used as autophagy inhibitors based on their inhibitory effect
on class III PI3K activity, which is known to be essential for induction of autophagy. In this
study, we systematically examined and compared the effects of these two inhibitors on
autophagy under both nutrient-rich and deprivation conditions. To our surprise, 3-MA is
found to promote autophagy flux when treated under nutrient-rich conditions with a …