Clinical and biological heterogeneity in acute respiratory distress syndrome: direct versus indirect lung injury
CM Shaver, JA Bastarache - Clinics in chest medicine, 2014 - chestmed.theclinics.com
Twenty years ago, the American-European Consensus Conference on ARDS emphasized
the complexity of the pathogenesis of acute respiratory distress syndrome (ARDS) and
suggested that separation of ARDS patients into more homogeneous subgroups could be a
useful strategy to facilitate understanding of this syndrome. The consensus panel authors
proposed 2 broad groups of patients with ARDS: those with direct injury to the lung
parenchyma and those with indirect lung injury in the setting of systemic inflammation. 1 …
the complexity of the pathogenesis of acute respiratory distress syndrome (ARDS) and
suggested that separation of ARDS patients into more homogeneous subgroups could be a
useful strategy to facilitate understanding of this syndrome. The consensus panel authors
proposed 2 broad groups of patients with ARDS: those with direct injury to the lung
parenchyma and those with indirect lung injury in the setting of systemic inflammation. 1 …