Heparan sulfate in the developing, healthy, and injured lung
SM Haeger, Y Yang, EP Schmidt - American journal of respiratory …, 2016 - atsjournals.org
SM Haeger, Y Yang, EP Schmidt
American journal of respiratory cell and molecular biology, 2016•atsjournals.orgRemarkable progress has been achieved in understanding the regulation of gene
expression and protein translation, and how aberrancies in these template-driven processes
contribute to disease pathogenesis. However, much of cellular physiology is controlled by
non-DNA, nonprotein mediators, such as glycans. The focus of this Translational Review is
to highlight the importance of a specific glycan polymer—the glycosaminoglycan heparan
sulfate (HS)—on lung health and disease. We demonstrate how HS contributes to lung …
expression and protein translation, and how aberrancies in these template-driven processes
contribute to disease pathogenesis. However, much of cellular physiology is controlled by
non-DNA, nonprotein mediators, such as glycans. The focus of this Translational Review is
to highlight the importance of a specific glycan polymer—the glycosaminoglycan heparan
sulfate (HS)—on lung health and disease. We demonstrate how HS contributes to lung …
Remarkable progress has been achieved in understanding the regulation of gene expression and protein translation, and how aberrancies in these template-driven processes contribute to disease pathogenesis. However, much of cellular physiology is controlled by non-DNA, nonprotein mediators, such as glycans. The focus of this Translational Review is to highlight the importance of a specific glycan polymer—the glycosaminoglycan heparan sulfate (HS)—on lung health and disease. We demonstrate how HS contributes to lung physiology and pathophysiology via its actions as both a structural constituent of the lung parenchyma as well as a regulator of cellular signaling. By highlighting current uncertainties in HS biology, we identify opportunities for future high-impact pulmonary and critical care translational investigations.
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