[HTML][HTML] A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK …

J Miyamoto, T Mizukure, SB Park, S Kishino… - Journal of Biological …, 2015 - ASBMB
Gut microbial metabolites of polyunsaturated fatty acids have attracted much attention
because of their various physiological properties. Dysfunction of tight junction (TJ) in the
intestine contributes to the pathogenesis of many disorders such as inflammatory bowel
disease. We evaluated the effects of five novel gut microbial metabolites on tumor necrosis
factor (TNF)-α-induced barrier impairment in Caco-2 cells and dextran sulfate sodium-
induced colitis in mice. 10-Hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial …