Oncometabolite accumulation and epithelial-to-mesenchymal transition: the turn of fumarate
M Janin, M Esteller - Cell metabolism, 2016 - cell.com
Cell metabolism, 2016•cell.com
Mutations to the Krebs cycle enzyme fumarate hydratase in cancer cells leads to an
accumulation of the oncometabolite fumarate. Sciacovelli et al.(2016) demonstrate an
epigenetically dependent epithelial-to-mesenchymal transition mediated by modulation of
the miR-200 cluster and TET demethylation in response to fumarate accumulation.
accumulation of the oncometabolite fumarate. Sciacovelli et al.(2016) demonstrate an
epigenetically dependent epithelial-to-mesenchymal transition mediated by modulation of
the miR-200 cluster and TET demethylation in response to fumarate accumulation.
Mutations to the Krebs cycle enzyme fumarate hydratase in cancer cells leads to an accumulation of the oncometabolite fumarate. Sciacovelli et al. (2016) demonstrate an epigenetically dependent epithelial-to-mesenchymal transition mediated by modulation of the miR-200 cluster and TET demethylation in response to fumarate accumulation.
cell.com
