The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia
M MacPhee, KP Chepenik, RA Liddell, KK Nelson… - Cell, 1995 - cell.com
M MacPhee, KP Chepenik, RA Liddell, KK Nelson, LD Siracusa, AM Buchberg
Cell, 1995•cell.comMutations in the APC gene are responsible for various familial and sporadic colorectal
cancers. Min mice carry a dominant mutation in the homolog of the Apc gene and develop
multiple adenomas throughout their small and large intestine. Quantitative trait loci studies
have identified a locus, Moml, which maps to the distal region of chromosome 4, that
dramatically modifies
cancers. Min mice carry a dominant mutation in the homolog of the Apc gene and develop
multiple adenomas throughout their small and large intestine. Quantitative trait loci studies
have identified a locus, Moml, which maps to the distal region of chromosome 4, that
dramatically modifies
Summary
Mutations in the APC gene are responsible for various familial and sporadic colorectal cancers. Min mice carry a dominant mutation in the homolog of the Apc gene and develop multiple adenomas throughout their small and large intestine. Quantitative trait loci studies have identified a locus, Moml, which maps to the distal region of chromosome 4, that dramatically modifies
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