[HTML][HTML] Role of charge properties of bacterial envelope in bactericidal action of human group IIA phospholipase A2against Staphylococcus aureus
Mammalian Group IIA phospholipases A 2 (PLA 2) potently killStaphylococcus aureus.
Highly cationic properties of these PLA 2 are important for Ca 2+-independent binding and
cell wall penetration, prerequisites for Ca 2+-dependent degradation of membrane
phospholipids and bacterial killing. To further delineate charge properties of the bacterial
envelope important in Group IIA PLA 2 action against S. aureus, we examined the effects of
mutations that prevent specific modifications of cell wall (dltA) and cell membrane (mprF) …
Highly cationic properties of these PLA 2 are important for Ca 2+-independent binding and
cell wall penetration, prerequisites for Ca 2+-dependent degradation of membrane
phospholipids and bacterial killing. To further delineate charge properties of the bacterial
envelope important in Group IIA PLA 2 action against S. aureus, we examined the effects of
mutations that prevent specific modifications of cell wall (dltA) and cell membrane (mprF) …