Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses
S Pelletier, C Drouin, N Bédard, SI Khakoo… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: Natural killer (NK) cells provide early defense against viral
infections by killing infected cells and producing cytokines that inhibit viral replication. NK
cells also interact with dendritic cells (DCs) and this reciprocal interaction regulates both
innate and adaptive immunity. Genetic studies have suggested that NK cell activity is a
determinant of HCV infectious outcome but a functional correlation has not been
established. We hypothesized that increased NK cell activity during acute HCV infection …
infections by killing infected cells and producing cytokines that inhibit viral replication. NK
cells also interact with dendritic cells (DCs) and this reciprocal interaction regulates both
innate and adaptive immunity. Genetic studies have suggested that NK cell activity is a
determinant of HCV infectious outcome but a functional correlation has not been
established. We hypothesized that increased NK cell activity during acute HCV infection …