KIR2DL3+ NKG2A− natural killer cells are associated with protection from productive hepatitis C virus infection in people who inject drugs
C Thoens, C Berger, M Trippler, H Siemann… - Journal of …, 2014 - Elsevier
Background & Aims Despite continuous high-risk behavior, a subgroup among people who
inject drugs (PWID) remains seronegative for hepatitis C virus (HCV) suggesting that a state
of “natural resistance” to HCV Infection may exist. Homozygosity for KIR2DL3 and its ligand
HLA-C1 group alleles has been associated with control of HCV infection, however, the
mechanism mediating this protective effect remained unclear. Methods Peripheral NK cells
from PWID (n= 104) were phenotypically and functionally characterized by multicolor flow …
inject drugs (PWID) remains seronegative for hepatitis C virus (HCV) suggesting that a state
of “natural resistance” to HCV Infection may exist. Homozygosity for KIR2DL3 and its ligand
HLA-C1 group alleles has been associated with control of HCV infection, however, the
mechanism mediating this protective effect remained unclear. Methods Peripheral NK cells
from PWID (n= 104) were phenotypically and functionally characterized by multicolor flow …