Aging is associated with a rapid decline in frequency, alterations in subset composition, and enhanced Th2 response in CD1d-restricted NKT cells from human …
Y Jing, S Gravenstein, NR Chaganty, N Chen… - Experimental …, 2007 - Elsevier
NKT cells are important for initiating and regulating immune responses. We investigated the
age-related changes in the CD1d-restricted semi-invariant NKT (iNKT) cells in peripheral
blood of healthy adults. The iNKT cell frequency was 2.5-to 10.7-fold less in healthy elderly
subjects (61years and over) compared to the healthy young subjects (20–40years, p<
0.001). This age-related decline in iNKT cells was observed both in freshly isolated PBMC
and in cultures where iNKT cells were enriched by α-GalCer stimulation using either the …
age-related changes in the CD1d-restricted semi-invariant NKT (iNKT) cells in peripheral
blood of healthy adults. The iNKT cell frequency was 2.5-to 10.7-fold less in healthy elderly
subjects (61years and over) compared to the healthy young subjects (20–40years, p<
0.001). This age-related decline in iNKT cells was observed both in freshly isolated PBMC
and in cultures where iNKT cells were enriched by α-GalCer stimulation using either the …
