Mechanisms of prolongation of allograft survival by HLA-G/ILT4-modified dendritic cells
V Ristich, W Zhang, S Liang, A Horuzsko - Human immunology, 2007 - Elsevier
Engagement of inhibitory receptors on dendritic cells (DCs) is a powerful way to modulate
their functions to achieve hyporesponsiveness or tolerance induction. Transgenic mice
expressing human ILT4 receptor exclusively on DCs and triggered by HLA-G1 developed
long-term survival of allogeneic skin transplant. Here we identify the cellular and molecular
mechanisms responsible for that induction of hyporesponsiveness to alloantigen in vivo.
Engagement of ILT4 receptor by HLA-G1 resulted in down-regulation of expression of MHC …
their functions to achieve hyporesponsiveness or tolerance induction. Transgenic mice
expressing human ILT4 receptor exclusively on DCs and triggered by HLA-G1 developed
long-term survival of allogeneic skin transplant. Here we identify the cellular and molecular
mechanisms responsible for that induction of hyporesponsiveness to alloantigen in vivo.
Engagement of ILT4 receptor by HLA-G1 resulted in down-regulation of expression of MHC …