Cutting edge: human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor γ-chain
H Nakajima, J Samaridis, L Angman… - The Journal of …, 1999 - journals.aai.org
H Nakajima, J Samaridis, L Angman, M Colonna
The Journal of Immunology, 1999•journals.aai.orgIg-like transcripts (ILTs) encode cell surface receptors expressed on myeloid and lymphoid
cells that are structurally and functionally related to killer cell inhibitory receptors. One ILT,
designated ILT1, contains a short cytoplasmic domain that lacks sequence motifs implicated
in signal transduction. Its function is unknown. Similar short cytoplasmic domains have been
observed in activating NK cell receptors and FcαR, which transduce stimulatory signals via
associated DAP12 and FcεRIγ proteins, respectively. Here we show that ILT1 receptor is …
cells that are structurally and functionally related to killer cell inhibitory receptors. One ILT,
designated ILT1, contains a short cytoplasmic domain that lacks sequence motifs implicated
in signal transduction. Its function is unknown. Similar short cytoplasmic domains have been
observed in activating NK cell receptors and FcαR, which transduce stimulatory signals via
associated DAP12 and FcεRIγ proteins, respectively. Here we show that ILT1 receptor is …
Abstract
Ig-like transcripts (ILTs) encode cell surface receptors expressed on myeloid and lymphoid cells that are structurally and functionally related to killer cell inhibitory receptors. One ILT, designated ILT1, contains a short cytoplasmic domain that lacks sequence motifs implicated in signal transduction. Its function is unknown. Similar short cytoplasmic domains have been observed in activating NK cell receptors and FcαR, which transduce stimulatory signals via associated DAP12 and FcεRIγ proteins, respectively. Here we show that ILT1 receptor is selectively expressed on myeloid cells, functions as an activating receptor, and associates with FcεRIγ rather than DAP12.
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