Soluble HLA-G and HLA-G1 expressing antigen-presenting cells inhibit T-cell alloproliferation through ILT-2/ILT-4/FasL-mediated pathways
A Naji, A Durrbach, ED Carosella, N Rouas-Freiss - Human immunology, 2007 - Elsevier
HLA-G is a tolerogenic molecule involved in maternal-fetal tolerance and in allograft
acceptance. Soluble HLA-G proteins are present at high levels in plasma from transplanted
patients who better accept their graft. In addition, infiltrating mononuclear cells expressing
HLA-G can be detected within grafted tissues. To define the role of these HLA-G proteins in
preventing graft rejection, we investigated the ability of HLA-G1 expressing antigen
presenting cells (APC) and of soluble HLA-G proteins (ie, HLA-G5 and shed HLA-G1) to …
acceptance. Soluble HLA-G proteins are present at high levels in plasma from transplanted
patients who better accept their graft. In addition, infiltrating mononuclear cells expressing
HLA-G can be detected within grafted tissues. To define the role of these HLA-G proteins in
preventing graft rejection, we investigated the ability of HLA-G1 expressing antigen
presenting cells (APC) and of soluble HLA-G proteins (ie, HLA-G5 and shed HLA-G1) to …