Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc
G Vlad, MB Stokes, Z Liu, CC Chang, H Sondermeijer… - Human immunology, 2009 - Elsevier
Allogeneic hematopoietic cell transplantation represents an important therapy for certain
malignant and nonmalignant diseases. However, graft-versus-host disease (GVHD) is a
major cause of mortality and morbidity. The search for agents that can efficiently suppress
GVHD has been going on for more than half a century. GVHD is particularly strong in
xenogeneic donor–recipient combinations, given the unlimited number of potentially
immunogenic antigens donor lymphocytes encounter in the host. Using a hu-nonobese …
malignant and nonmalignant diseases. However, graft-versus-host disease (GVHD) is a
major cause of mortality and morbidity. The search for agents that can efficiently suppress
GVHD has been going on for more than half a century. GVHD is particularly strong in
xenogeneic donor–recipient combinations, given the unlimited number of potentially
immunogenic antigens donor lymphocytes encounter in the host. Using a hu-nonobese …