[HTML][HTML] Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer
M Shiroishi, K Kuroki, T Ose, L Rasubala… - Journal of Biological …, 2006 - ASBMB
HLA-G is a nonclassical major histocompatibility complex class I (MHCI) molecule, which is
expressed in trophoblasts and confers immunological tolerance in the maternal-fetal
interface by binding to leukocyte Ig-like receptors (LILRs, also called as LIR/ILT/CD85) and
CD8. HLA-G is expressed in disulfide-linked dimer form both in solution and at the cell
surface. Interestingly, MHCI dimer formations have been involved in pathogenesis and T cell
activation. The structure and receptor binding characteristics of MHCI dimers have never …
expressed in trophoblasts and confers immunological tolerance in the maternal-fetal
interface by binding to leukocyte Ig-like receptors (LILRs, also called as LIR/ILT/CD85) and
CD8. HLA-G is expressed in disulfide-linked dimer form both in solution and at the cell
surface. Interestingly, MHCI dimer formations have been involved in pathogenesis and T cell
activation. The structure and receptor binding characteristics of MHCI dimers have never …