Neutrophils and contact activation of coagulation as potential drivers of COVID-19

MH Busch, SA Timmermans, M Nagy, M Visser… - Circulation, 2020 - Am Heart Assoc
MH Busch, SA Timmermans, M Nagy, M Visser, J Huckriede, JP Aendekerk, F de Vries…
Circulation, 2020Am Heart Assoc
Ranges indicate IQR. bold indicates significant observations; Ct, cycle time. The detection
limit of extracellular histone H3 was 0.005 µg/mL. Differences between groups were
analyzed by unpaired sample t test, Mann-Whitney U test, 1-way ANOVA, or Kruskal-Wallis.
Differences in categorical variables were analyzed by χ2 test or Fisher exact test when
appropriate; significant differences between patients groups: progressive/severe versus*
moderate or† mild disease; moderate versus‡ mild disease. α1AT indicates α1-antitrypsin; …
Ranges indicate IQR. bold indicates significant observations; Ct, cycle time. The detection limit of extracellular histone H3 was 0.005 µg/mL. Differences between groups were analyzed by unpaired sample t test, Mann-Whitney U test, 1-way ANOVA, or Kruskal-Wallis. Differences in categorical variables were analyzed by χ2 test or Fisher exact test when appropriate; significant differences between patients groups: progressive/severe versus* moderate or† mild disease; moderate versus‡ mild disease. α1AT indicates α1-antitrypsin; AST, aspartate transaminase; AT, antithrombin; C1INH, C1 esterase inhibitor; COPD, chronic obstructive pulmonary disease; CRP, C-reactive protein; Ct, cycle time; CVA, cerebrovascular accident; DBP, diastolic blood pressure; F, female; FIXa, activated factor IX; FXIa, activated factor XI; LDH, lactate dehydrogenase; M, male; NETosis, neutrophil extracellular trap-osis; PKa, plasma kallikrein; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; SBP, systolic blood pressure; TAT, thrombin in complex with antithrombin; and vWF: Ag, von Willebrand factor antigen.‡ Significant observations.
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