Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT1 receptors
J Peti-Peterdi, DG Warnock, PD Bell - Journal of the American …, 2002 - journals.lww.com
Angiotensin II (AngII) helps to regulate overall renal tubular reabsorption of salt and water,
yet its effects in the distal nephron have not been well studied. The purpose of these studies
was to determine whether AngII stimulates luminal Na+ transport in the cortical collecting
duct (CCD). Intracellular Na+ concentration ([Na+] i), as a reflection of Na+ transport across
the apical membrane, was measured with fluorescence microscopy using sodium-binding
benzofuran isophthalate (SBFI) in isolated, perfused CCD segments dissected from rabbit …
yet its effects in the distal nephron have not been well studied. The purpose of these studies
was to determine whether AngII stimulates luminal Na+ transport in the cortical collecting
duct (CCD). Intracellular Na+ concentration ([Na+] i), as a reflection of Na+ transport across
the apical membrane, was measured with fluorescence microscopy using sodium-binding
benzofuran isophthalate (SBFI) in isolated, perfused CCD segments dissected from rabbit …