Due to improved survival and clinical outcomes, congenital heart disease (CHD) is an area
of growing importance within the medical community. As these patients reach adulthood and
have children, there has been a growing appreciation for the increased risk of CHD among
their offspring, strongly implying a genetic element. Given the growing wealth of genetic data
available and these clinical implications, this review serves to reexamine the role of genetics
within CHD, using Tetralogy of Fallot as a model pathology. Tetralogy of Fallot (TOF) is one …