Radiosynthesis and validation of [Carboxy11C]4‐Aminobenzoic acid ([11C]PABA), a PET radiotracer for imaging bacterial infections

DP Holt, AS Kalinda, LE Bambarger… - Journal of Labelled …, 2019 - Wiley Online Library
Journal of Labelled Compounds and Radiopharmaceuticals, 2019Wiley Online Library
In this practitioner protocol, the radiochemical synthesis of [11C] PABA is described in detail,
and a quality control summary of three validation productions is presented. The results
indicate that the radiotracer product can be produced in good radiochemical yield (14% at
end‐of‐synthesis (EOS)) at high specific activity (molar activity 11 Ci/μmole EOS; 407
GBq/μmole) and high chemical and radiochemical purity as a sterile, pyrogen‐free solution
suitable for injection conforming to current Good Manufacturing Practice (cGMP) …
In this practitioner protocol, the radiochemical synthesis of [11C] PABA is described in detail, and a quality control summary of three validation productions is presented. The results indicate that the radiotracer product can be produced in good radiochemical yield (14% at end‐of‐synthesis (EOS)) at high specific activity (molar activity 11 Ci/μmole EOS; 407 GBq/μmole) and high chemical and radiochemical purity as a sterile, pyrogen‐free solution suitable for injection conforming to current Good Manufacturing Practice (cGMP) requirements.
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