Arylamine N-acetyltransferases–from drug metabolism and pharmacogenetics to identification of novel targets for pharmacological intervention

E Sim, G Fakis, N Laurieri, S Boukouvala - Advances in pharmacology, 2012 - Elsevier
Arylamine N-acetyltransferases (NATs) are defined as xenobiotic metabolizing enzymes,
adding an acetyl group from acetyl coenzyme A (CoA) to arylamines and arylhydrazines.
NATs are found in organisms from bacteria and fungi to vertebrates. Several isoenzymes,
often polymorphic, may be present in one organism. There are two functional polymorphic
NATs in humans and polymorphisms in NAT2 underpinned pharmacogenetics as a
discipline. NAT enzymes have had a role in important metabolic concepts: the identification …