[HTML][HTML] Evaluating tumor heterogeneity in immunohistochemistry-stained breast cancer tissue
SJ Potts, JS Krueger, ND Landis, DA Eberhard… - Laboratory …, 2012 - Elsevier
Quantitative clinical measurement of heterogeneity in immunohistochemistry staining would
be useful in evaluating patient therapeutic response and in identifying underlying issues in
histopathology laboratory quality control. A heterogeneity scoring approach (HetMap) was
designed to visualize a individual patient's immunohistochemistry heterogeneity in the
context of a patient population. HER2 semiquantitative analysis was combined with ecology
diversity statistics to evaluate cell-level heterogeneity (consistency of protein expression …
be useful in evaluating patient therapeutic response and in identifying underlying issues in
histopathology laboratory quality control. A heterogeneity scoring approach (HetMap) was
designed to visualize a individual patient's immunohistochemistry heterogeneity in the
context of a patient population. HER2 semiquantitative analysis was combined with ecology
diversity statistics to evaluate cell-level heterogeneity (consistency of protein expression …