[HTML][HTML] Immunohistochemical detection of PD-L1 among diverse human neoplasms in a reference laboratory: observations based upon 62,896 cases
DP O'Malley, Y Yang, S Boisot, S Sudarsanam… - Modern Pathology, 2019 - Elsevier
Targeting of the PD1/PD-L1 immune checkpoint pathway has rapidly gained acceptance as
a therapeutic strategy for a growing number of malignancies. Testing for expression of PD-
L1 in tumor cells and immune cells has been used as a companion or complementary test
for drugs targeting the PD1/PD-L1 pathway. We evaluated the results of PD-L1 testing in a
large reference lab cohort. Using Food and Drug Administration-approved methods and
interpretive instructions for each individual test, 62,896 cases were evaluated for PD-L1 …
a therapeutic strategy for a growing number of malignancies. Testing for expression of PD-
L1 in tumor cells and immune cells has been used as a companion or complementary test
for drugs targeting the PD1/PD-L1 pathway. We evaluated the results of PD-L1 testing in a
large reference lab cohort. Using Food and Drug Administration-approved methods and
interpretive instructions for each individual test, 62,896 cases were evaluated for PD-L1 …